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     <h4> Principal Investigators </h4>
 
     <h4> Principal Investigators </h4>
 
       <h5>  
 
       <h5>  
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      <h4> Core Personnel </h4> <h5>
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  <table class="table table-hover">
 
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             <tbody>
 
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                             <td id="az" class="col-md-1">   
 
                             <td id="az" class="col-md-1">   
                                       <a href="http://cci.case.edu/cci/index.php/Cpj3"> <img src="http://cci.case.edu/cci/images/1/16/Jayapadian.jpg"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>  
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                                       <a href="Nuria website link for image"> <img src="image"  width="64px" height="72px" alt="/images/7/72/Sample_image.jpg"> </a>  
 
                             </td>
 
                             </td>
 
                             <td class="col-md-11">  
 
                             <td class="col-md-11">  
                                       <h5 style="color:#93322d;"> <a href="">Catherine P Jayapandian, PhD </a> </h5>  
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                                       <h5 style="color:#93322d;"> <a href="">Nuria Lacuey-Lecumberri, MD </a> </h5>  
                                       <p> Dr. Jayapandian is a Research Associate in the Medical Informatics Core in the Center for Clinical Investigation, CWRU. Her research interests include High Performance Computing on Hadoop, Agile Web Development with Ruby on Rails, Semantic Web - Provenance Metadata Management, Knowledge Representation and Medical Image Processing and Visualization </p>
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                                       <p> Dr. Lecumberri  is a Clinical Fellow in the  </p>
 
                             </td>
 
                             </td>
 
                 </tr>
 
                 </tr>
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                 <tr>
 
                 <tr>
 
                             <td id="az" class="col-md-1">   
 
                             <td id="az" class="col-md-1">   
                                       <a href="http://casemed.case.edu/dept/neurology/tatsuoka.html"> <img src="http://casemed.case.edu/dept/neurology/CT.jpg"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>  
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                                       <a href="website link for image"> <img src="image"  width="64px" height="72px" alt="/images/7/72/Sample_image.jpg"> </a>  
 
                             </td>
 
                             </td>
 
                             <td class="col-md-11">  
 
                             <td class="col-md-11">  
                                       <h5 style="color:#93322d;"> <a href="">Curtis Tatsuoka, PhD </a> </h5>  
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                                       <h5 style="color:#93322d;"> <a href="">Dr. Lhatoo, MD, FRCP </a> </h5>  
                                       <p>  Dr. Tatsuoka is the Director of Biostatistics at the University Hospitals Case Medical Center.</p>
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                                       <p>  Dr. Lhatoo is .</p>
 
                             </td>
 
                             </td>
 
                 </tr>
 
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                             <td id="az" class="col-md-1">   
 
                             <td id="az" class="col-md-1">   
                                       <a href="http://cci.case.edu/cci/index.php/Jem200"> <img src="http://cci.case.edu/cci/images/8/87/Jem200.jpg"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>  
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                                       <a href="Sandhya Rani"> <img src="image"  width="64px" height="72px" alt="/images/7/72/Sample_image.jpg"> </a>  
 
                             </td>
 
                             </td>
 
                             <td class="col-md-11">  
 
                             <td class="col-md-11">  
                                       <h5 style="color:#93322d;"> <a href="">Jeno Mozes, MS </a> </h5>  
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                                       <h5 style="color:#93322d;"> <a href="">Sandhya Rani, PhD</a> </h5>  
                                       <p> Mozes is a Programmer Analyst, Medical Informatics Core in the Center for Clinical Investigation, CWRU. </p>
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                                       <p> Dr. Rani is the </p>
 
                             </td>
 
                             </td>
 
                 </tr>
 
                 </tr>
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                 <tr>
 
                 <tr>
 
                             <td id="az" class="col-md-1">   
 
                             <td id="az" class="col-md-1">   
                                       <a href="http://engineering.case.edu/profiles/kal4"> <img src="http://www.bu.edu/ece/files/2010/02/LoparoNew.jpg"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>  
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                                       <a href="Bilal Zonjy image file link"> <img src="image"  width="64px" height="72px" alt="/images/7/72/Sample_image.jpg"> </a>  
 
                             </td>
 
                             </td>
 
                             <td class="col-md-11">  
 
                             <td class="col-md-11">  
                                       <h5 style="color:#93322d;"> <a href="">Kenneth A Loparo, PhD </a> </h5>  
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                                       <h5 style="color:#93322d;"> <a href="">Bilal Zonjy, MD</a> </h5>  
                                       <p> Dr. Loparo is the Nord Professor and Chair Department of Electrical Engineering and Computer Science, CWRU. His research interests include stability and control of nonlinear and stochastic systems with applications to large-scale electricity systems including generation and transmission and distribution; nonlinear filtering with applications to monitoring, fault detection, diagnosis, prognosis and reconfigurable control; information theory aspects of stochastic and quantized systems with applications to adaptive and dual control and the design of distributed autonomous control systems; the development of advanced signal processing and data analytics for monitoring and tracking of physiological behavior in health and disease. </p>
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                                       <p> Dr. Zonjy is a clinical epileptologist...</p>
                            </td>
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                            <td id="az" class="col-md-1"> 
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                                      <a href="http://cci.case.edu/cci/index.php/Lxc248"> <img src="http://cci.case.edu/cci/images/8/80/Lxc248.jpg"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>
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                            </td>
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                            <td class="col-md-11">
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                                      <h5 style="color:#93322d;"> <a href="">Licong Cui, PhD </a> </h5>
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                                      <p> Dr. Cui is a Research Assistant Professor in the Department of Electrical Engineering and Computer Science and Division of Medical Informatics at Case Western Reserve University. Her research interests include Information retrieval, Text mining, Semantic web, Data integration and management, Big data analytics and Biomedical Informatics </p>
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                            </td>
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                </tr>
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                <tr>
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                            <td id="az" class="col-md-1"> 
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                                      <a href="http://cci.case.edu/cci/index.php/Satya_Sahoo"> <img src="http://cci.case.edu/cci/images/2/28/Satya_sahoo.png"  width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>
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                            </td>
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                            <td class="col-md-11">
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                                      <h5 style="color:#93322d;"> <a href="">Satya S Sahoo, PhD </a> </h5>
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                                      <p> Dr. Sahoo is an assistant professor in the Division of Medical Informatics and Department of Electrical Engineering and Computer Science. His research interests include development of computer science methods and technologies for: clinical big data - massive scale distributed computing over electrophysiological signal data, patient information capture at the point of care (OPIC project), natural language processing (NLP) over clinical free text. </p>
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                            </td>
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                </tr>
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                <tr>
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                            <td id="az" class="col-md-1"> 
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                                      <a href="http://cci.case.edu/cci/index.php/Sxt286"> <img src="http://cci.case.edu/cci/images/6/6f/ShiqiangTao1.jpg" width="64px" height="72px" alt="/csr/images/7/72/Sample_image.jpg"> </a>
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                            </td>
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                            <td class="col-md-11">
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                                      <h5 style="color:#93322d;"> <a href="">Shiqiang Tao, MS </a> </h5>
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                                       <p> </p>
 
                                       <p> </p>
 
                             </td>
 
                             </td>
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<li> Wandschneider B, Koepp M, Scott C, Micallef C, Balestrini S, Sisodya S, Thom M, Harper R, Sander J, Vos S, Duncan J, Lhatoo S, Diehl B.
 +
Structural imaging biomarkers of sudden unexpected death in epilepsy (Accepted, Brain 2015).
 
<li>Ryvlin P, Nashef L, Lhatoo SD, Bateman LM et al. Incidence and mechanisms of cardiorespiratory arrests
 
<li>Ryvlin P, Nashef L, Lhatoo SD, Bateman LM et al. Incidence and mechanisms of cardiorespiratory arrests
 
in epilepsy monitoring units (MORTEMUS): a retrospective study. [http://www.ncbi.nlm.nih.gov/pubmed/24012372 PMID 24012372].
 
in epilepsy monitoring units (MORTEMUS): a retrospective study. [http://www.ncbi.nlm.nih.gov/pubmed/24012372 PMID 24012372].
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                     <a href="#">Highlight 1</a>
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                     <a href="#">Regional grey matter volume differences between SUDEP,  people at high risk and controls</a>
 
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                 <p>Figure modified from:
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Structural imaging biomarkers of sudden unexpected death in epilepsy:
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Britta Wandschneider et al., Brain 2015, in press
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Latest revision as of 09:54, 1 July 2015


The Autonomic and Imaging Biomarkers of SUDEP (NS090407)


Specific Aims and Tasks

Sudden Unexpected Death in Epilepsy (SUDEP) affects ~3000 individuals with epilepsy in the USA annually. Death results from profound breathing and/or cardiovascular dysfunction, but mechanisms underlying failure, and risk factors identifying those most at risk are unknown. Our goal is to identify patterns of physiological dysfunction surrounding seizure periods and the underlying neural injury contributing to those patterns. We aim to identify patterns of physiological dysfunction (changes in blood pressure, heart rate, arrhythmia, breathing and EEG patterns) surrounding seizure periods and the underlying neural injury (focal structural brain changes identified through brain imaging including MRI) contributing to those patterns.
  • This project will provide insight into mechanisms of failure in SUDEP, and suggest pre-mortem characteristics that lead to a fatal scenario that are suitable for targeted intervention.

Principal Investigators



Publication Links

  • Wandschneider B, Koepp M, Scott C, Micallef C, Balestrini S, Sisodya S, Thom M, Harper R, Sander J, Vos S, Duncan J, Lhatoo S, Diehl B. Structural imaging biomarkers of sudden unexpected death in epilepsy (Accepted, Brain 2015).
  • Ryvlin P, Nashef L, Lhatoo SD, Bateman LM et al. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study. PMID 24012372.
  • Bozorgi A, Chung S, Kaffashi F, Loparo KA, Sahoo SS, Zhang GQ, Kaiboriboon K, Lhatoo SD. Significant peri-ictal hypotension: Expanding the spectrum of seizure induced autonomic dysregulatory phenomena with polygraphy. PMID 23758665.
  • Lhatoo SD, Faulkner HJ, Dembny K, Trippick K, Johnson C, Bird JM (2010). An electroclinical case-control study of sudden unexpected death in epilepsy. PMID 20882604.
  • Lhatoo SD, Johnson AL, Goodridge DM, MacDonald BK, Sander JW, Shorvon SD. Mortality in epilepsy in the first 11 to 14 years after diagnosis: Multivariate analysis of a long-term, prospective, population-based cohort. PMID 11261508.




Regional grey matter volume differences between SUDEP, people at high risk and controls

Figure modified from: Structural imaging biomarkers of sudden unexpected death in epilepsy: Britta Wandschneider et al., Brain 2015, in press