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The Autonomic and Imaging Biomarkers of SUDEP (NS090407)

Specific Aims and Tasks

Sudden Unexpected Death in Epilepsy (SUDEP) affects ~3000 individuals with epilepsy in the USA annually. Death results from profound breathing and/or cardiovascular dysfunction, but mechanisms underlying failure, and risk factors identifying those most at risk are unknown. Our goal is to identify patterns of physiological dysfunction surrounding seizure periods and the underlying neural injury contributing to those patterns. We aim to identify patterns of physiological dysfunction (changes in blood pressure, heart rate, arrhythmia, breathing and EEG patterns) surrounding seizure periods and the underlying neural injury (focal structural brain changes identified through brain imaging including MRI) contributing to those patterns.
  • This project will provide insight into mechanisms of failure in SUDEP, and suggest pre-mortem characteristics that lead to a fatal scenario that are suitable for targeted intervention.

Principal Investigators

Publication Links

  • Ryvlin P, Nashef L, Lhatoo SD, Bateman LM et al. Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study. PMID 24012372.
  • Bozorgi A, Chung S, Kaffashi F, Loparo KA, Sahoo SS, Zhang GQ, Kaiboriboon K, Lhatoo SD. Significant peri-ictal hypotension: Expanding the spectrum of seizure induced autonomic dysregulatory phenomena with polygraphy. PMID 23758665.
  • Lhatoo SD, Faulkner HJ, Dembny K, Trippick K, Johnson C, Bird JM (2010). An electroclinical case-control study of sudden unexpected death in epilepsy. PMID 20882604.
  • Lhatoo SD, Johnson AL, Goodridge DM, MacDonald BK, Sander JW, Shorvon SD. Mortality in epilepsy in the first 11 to 14 years after diagnosis: Multivariate analysis of a long-term, prospective, population-based cohort. PMID 11261508.