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IMNM

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iPSC and Mouse Neurocardiac Models (NS090364)


Specific Aims and Tasks

Utilize iPSC-derived cardiac myocytes and autonomic neurons as well as mouse models to determine whether heart rhythm disturbances are a cause of SUDEP in Dravet Syndrome, a severe childhood epilepsy with a high risk of SUDEP
  • Focus on SCN1A and SCN1B mutations and investigation of their effect on cardiac and autonomic neuron excitability

Principal Investigators



Citations



Protocols and Manuals



Publication Links



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